MAPT and Alzheimer disease: Alzheimer’s disease (AD), the most common form of dementia, has pathophysiological characteristics that include amyloid plaques, which are extracellular deposits of beta-amyloid (Aβ) in the brain parenchyma; cerebral amyloid angiopathy, which is the accumulation of Aβ in the cerebral blood vessels; and neurofibrillary tangles, which are deposits of hyper-phosphorylated tau protein inside neurons [1].