Therapeutically, several of the components of the APP machinery could be targeted in order to enhance the immunogenicity of cancer: the ubiquitin-proteasome degradation pathway, cytosolic peptidases, the TAP transporter, the peptide loading complex, peptide editing chaperones such as Tapasin or TAPBPR, ER aminopeptidases, and the MHCI themselves. This evidence concerns the gene APP and cancer.