As analyzed, patients with high AFP (≥400 ng/mL, hazard ratio (HR):1.556, p = 0.019), multiple tumor number (tumor number >1, HR:2.111, p < 0.001), presence of microvascular vascular invasion (HR:1.798, p = 0.001), advanced T stage (T2 or T3, HR: 2.085 and 2.582, p = 0.010 and p < 0.001, respectively), advanced staging (stage III and IV versus stage I and II, HR:2.574, p < 0.001), low expression level of Tid1 in the non-tumorous part (p = 0.054), and high Nrf2 expression in the non-tumorous part (p = 0.050) had an unfavorable recurrence-free survival (RFS) in univariate analysis. The gene discussed is AFP; the disease is neoplasm.