[53] Interestingly, the recurrent patterns categorized by Tid1 and Nrf2 in the non-tumor part indicate that the tumor suppressor effect of Tid1 might play a more important role for late recurrence, while the oxidative stress effect of Nrf2 is responsible for both early and late recurrence (Figure 3D,E). This evidence concerns the gene NFE2L2 and neoplasm.