The enveloped, negative-sense, single-strand RNA virus utilizes three host cell receptors for infection, including the membrane cofactor protein CD46 (cluster of differentiation 46), signaling lymphocytic activation molecule (SLAM; or CD150), and the tumor marker Nectin-4 (or poliovirus receptor related protein 4; PVRL4) overexpressed in adenocarcinomas [14,15,16,17,18,19]. The gene discussed is NECTIN4; the disease is adenocarcinoma.