Furthermore, caspase-1-dependent pyroptosis occurred in INR1G9 tumor cells upon magnetic intra-lysosomal hyperthermia generated by the combination of targeted magnetic nanoparticles and an alternating magnetic field through leakage of lysosomal cathepsins into the cytosol, providing a strategy to induce caspase-1 activation selectively in tumor cells [136]. The gene discussed is CASP1; the disease is neoplasm.