Reduced levels of IL-1β, TNF-α and IL-6 were detected in the NLRC4-siRNA group, compared with the sham and NC-siRNA groups (all pCLP vs. NLRC4-siRNA < 0.001; pNC-siRNA vs. NLRC4-siRNA < 0.001), which suggested that NLRC4 gene silencing alleviated the inflammatory reaction induced by septic shock. This evidence concerns the gene IL1B and Shock.