KEGG pathway enrichment analysis (Supplementary Table S6) showed that upregulated 3p-miRNAs, among others, are strongly associated with various cancer-related processes, such as ‘TGF-beta signaling pathway’, ‘Pathways in cancer’, ‘ErbB signaling pathway’ and ‘Hippo signaling pathway’, which were found among the top ten most significant associations (adjusted P <0.00001). Here, EGFR is linked to cancer.