As shown in Figure 5B and C, the examples of miR-329-3p and miR-380-5p (both members of the MIR-154 family playing a role in pulmonary fibrosis and being a target of TGFB signaling (115)) illustrate that miRNA level changes identified in the pan-cancer analysis are also reflected in the most frequently mutated cancers, i.e. COAD and READ. The gene discussed is TGFB1; the disease is cancer.