Of these mutations, we found p.E518K in DGCR8 occurring in two of 495 (0.4%) cases of THCA, p.R440Ter in XPO5 in one case of UCEC and one case of SKCM, and p.D1151E in DROSHA in one case of COAD (Supplementary Figure S3). This evidence concerns the gene DROSHA and colon adenocarcinoma.