Other interesting examples included AGO4, LIN28A and SMAD2 overmutated in BLCA (an otherwise extremely low-mutation cancer with no mutations in other genes); LIN28B overmutated in SKCM; PRKRA overmutated in OV; and DDX5 overmutated in BRCA and KIRP. The gene discussed is SMAD2; the disease is cancer.