[Chi-square was 0.129, 0.21 and 1.43 (P value ≥ 0.05).] Comparison of the MTHFR 1298 and 677 polymorphisms between each of the cervical intraepithelial neoplasia subjects, HPV-infected cases and non-cancer/non-HPVs control indicated a significant difference in some genotypes. The gene discussed is MTHFR; the disease is cancer.