As shown here, IgM index on Chikungunya and SARS-CoV-2 co-infection samples was significantly reduced (p<0.0001) when compared to Chikungunya infection alone (Fig 7A), and undistinguishable when Dengue and Dengue/SARS-CoV-2 were compared (Fig 7B). Here, CD40LG is linked to dengue disease.