Our findings demonstrated that an existing positive IgM test result for either Dengue or Chikungunya infections may prevent the early diagnosis of SARS-CoV-2 infections; since SARS-CoV-2 and arboviral diseases share similar features, the presence of a positive IgM result for either Dengue or Chikungunya may deceive clinicians to do not consider SARS-CoV-2 as a potential cause for the observed symptoms. Here, CD40LG is linked to dengue disease.