SELP and Mental deterioration: Some other studies investigated candidate genes regulating biologic pathways for inflammation, cell matrix adhesion/interaction, coagulation‐thrombosis, lipid metabolism, vascular reactivity, and drug metabolism which are associated with incidence of POCD (Mathew, Podgoreanu, & Grocott, 2007; Steinmetz et al., 2012), suggesting P‐selectin and CRP genes in modulating susceptibility to cognitive decline after cardiac surgery.