Some of the genes that were similarly modulated by MR766 and Rio-U1 related to cytokine signaling (CXCL10/11, CCL8) and the IFN response (IFIT2, ISG15, OAS2, DDX58, among others) (Fig. S2a), suggesting some degree of similarity in signaling patterns following infection with either virus. Here, ISG15 is linked to infection.