Some of the genes that were similarly modulated by MR766 and Rio-U1 related to cytokine signaling (CXCL10/11, CCL8) and the IFN response (IFIT2, ISG15, OAS2, DDX58, among others) (Fig. S2a), suggesting some degree of similarity in signaling patterns following infection with either virus. The gene discussed is OAS2; the disease is infection.