The levels of both high-sensitivity troponin I and NT-pro-BNP are increased in patients with COVID-19 presenting with cardiac damage, and troponin has an independent prognostic value for both COVID-19 and HF; however, as a non-independent prognostic marker, NT-pro-BNP is not specific for the diagnosis of concomitant HF in patients with COVID-19 [78, 85]. The gene discussed is NPPB; the disease is hydrops fetalis.