EGFR and cancer: Chromatin target of PRMT1 (CHTOP), when associated with 5-hydroxymethylcytosine (5hmC), recruits PRMT1 as part of the methylosome complex, which then stimulates the expression of cancer-related genes EGFR, AKT3, cyclin-dependent kinase (CDK6), cyclin D2 (CCND2), and rapidly accelerated fibrosarcoma oncogene B-homolog (BRAF), through the methylation of H4R3.