MiR-543 has been shown to bind to the 3′-UTR of PRMT9, which inhibits PRMT9 expression and leads to reduced PRMT9-driven cell oxidative phosphorylation and increased hypoxia-induced factor-1α (HIF-1α) stability in osteosarcoma cells (Zhang et al. 2017). This evidence concerns the gene PRMT9 and osteosarcoma.