EGFR and cancer: The possible role of cross-talk between ArgMe and phosphorylation in cancer has been an outstanding question in the field since the publication of the classic paper by Hsu and coworkers that described cross-talk between EGFR R1175 methylation and Y1173 phosphorylation, which was reported to modulate cell proliferation, migration and invasion of EGFR-expressing cells (Hsu et al. 2011).