RYR2 and catecholaminergic polymorphic ventricular tachycardia: Liu et al. [49] demonstrated that CaMKII inhibition with pharmacological inhibitor KN93 or inhibitory peptide AIP reduces spontaneous SR Ca2+ release and thereby triggered activity in the form of DADs in cardiomyocytes from RyR2-R4496C(+/−) KI CPVT mice.