RYR2 and catecholaminergic polymorphic ventricular tachycardia: Importantly, mito-ROS scavenging with the mitochondrial-targeted antioxidant mito-TEMPO reduced RyR2 oxidation, restored SR Ca2+ content, and reduced incidence of pro-arrhythmic spontaneous Ca2+ waves in β-adrenergic agonist-treated cardiomyocytes from the CASQ2 knock out (KO) CPVT mouse model [34].