Use of SGI-1027, a DNMT pan-inhibitor (DNMT1/DNMT3A/DNMT3B), and nanomycin A, a DNMT3B inhibitor in NB cell lines, resulted in a higher cytotoxicity when given alone or in combinatorial treatment with doxorubicin, and this effect was independent of the MYCN amplification status [42]. Here, DNMT1 is linked to neuroblastoma.