With this work, RalA and RalB add to the list of proteins known to control exosome secretion and to affect tumor progression, such as Rab27a (Bobrie et al., 2012; Kren et al., 2020; Peinado et al., 2012), Alix (Monypenny et al., 2018), syntenin (Das et al., 2019), and components of the ESCRT machinery (Mattissek and Teis, 2014). The gene discussed is RALB; the disease is neoplasm.