NOTCH3 and CADASIL: Moreover, if coupled with simulations of blood vessel mechanics during aging, the model might shed light on the effects that age-related modifications have on Notch3-Jag1 signaling and, in turn, on the appearance of CADASIL symptoms in young adults.16 Finally, the Notch circuit model could be extended to include other Notch receptors, with different effects and behaviors, thereby enabling the investigation of ALGS dose sensitivity and Notch receptor specificity, which was discussed in the section on in vivo mouse models.