Selective inhibition of EZH2 in multiple HCC cell lines significantly increased the expression of NKG2D ligands, including UL16-binding protein 1–6 (ULBP1–6), major histocompatibility complex class I chain-related gene A (MICA), major histocompatibility complex class I chain-related gene B (MICB), CD112, and CD155 (Fig. 2). Here, EZH2 is linked to hepatocellular carcinoma.