CD40LG and Alzheimer disease: The study included 3,432 elderly patients (53.9% women, mean age at inclusion 62.7 ± 14.4 years) with an average follow-up time of 11.3 years. They observed a baseline increased serum level of anti-HSV IgM antibodies associated with an increased risk of developing AD (Hazard ratio: 1.96, p = 0.012).