CEACAM5 and neoplasm: In addition, in vitro experiments have demonstrated that the CEA receptor on the surface of macrophages after differentiation induction can combine with CEA and induce macrophages to rapidly secrete a large amount of tumor necrosis factor (TNFa), interleukin-1 (IL-l), interleukin-6 (IL-6), interleukin-10, and other cytokines, which affect tumor immunity via multiple mechanisms 22.