EZH2 and nasopharyngeal carcinoma: Epigenetic regulator EZH2 was regulated by tumor suppressor MIR150 and MIR137. Transcription factor SOX4 was over-expressed in all expression datasets and regulated by MIR129 and MIR212. The expression of MIR212 has been reported to be decreased in NPC tissues and cells, and its overexpression could inhibit the metastasis of nasopharyngeal carcinoma by targeting SOX441; patients with higher expression levels of SOX4 had poorer survival rates 42.