Nuclear import of HIF-1A as a transcription factor is a hallmark event in HIF-1 dependant hundreds of target gene activation, such as angiogenic gene including VEGF-A, Flt-1, ang-1, MMP-2 and MMP-9 which promotes tumour angiogenesis, metastasis and clinical prognosis 29. This evidence concerns the gene MMP2 and neoplasm.