HIF1A and metastatic malignant neoplasm in the lymph nodes: We found lymph node metastasis [p = 0.032, HR (hazard ratio) = 2.435, 95% CI: 1.078-5.502] and nuclear HIF-1A expression [p =0.002, HR (hazard ratio) = 2.129, 95% CI: 1.308-3.466] as independent prognostic factors for OS in GBC patients (Table 7).