The results shown in Figure 6 indicated that CCNE2, CCNB1, CCNB2, BUB1B, TTK, CDC20 and PTTG1 were all highly expressed in BC cell lines (MCF-7 and MDA-MB-231), and there were significant differences (p<0.05) when compared to the MCF-10A cell line. The gene discussed is BUB1B; the disease is breast cancer.