Subsequently, multivariate analysis showed that high FOXD1 expression was an independent risk factor for RFS in patients with HNSCC (HR = 1.650, 95% CI: 1.058-2.575, P = 0.008) after adjustment for significant prognostic clinicpathological parameters (smoking history and pathologic stage). This evidence concerns the gene FOXD1 and head and neck squamous cell carcinoma.