The expression of METTL3, METTL14, WTAP, YTHDC2, YTHDF1, and YTHDF2 was remarkably higher in CRPC with lymph node metastasis than in CRPC with bone metastasis, whereas ALKBH5, FTO, and YTHDF3 were substantially decreased in CRPC with lymph node metastasis. The gene discussed is YTHDF3; the disease is metastatic malignant neoplasm in the lymph nodes.