These findings suggest that METTL3, METTL14, ALKBH5, FTO, YTHDC2, YTHDF1, and YTHDF2 were abnormally expressed in PCa and related to Gleason classification, and these m6A modulators were the potential molecular targets for the diagnosis and treatment for PCa. This evidence concerns the gene ALKBH5 and posterior cortical atrophy.