The expression of METTL3, METTL14, WTAP, YTHDC2, YTHDF1, and YTHDF2 was remarkably higher in CRPC with lymph node metastasis than in CRPC with bone metastasis, whereas ALKBH5, FTO, and YTHDF3 were substantially decreased in CRPC with lymph node metastasis. This evidence concerns the gene YTHDF2 and metastatic malignant neoplasm in the lymph nodes.