PDK1 and ovarian cancer: It had been reported that PDK1 was remarkably overexpressed in various tumors such as lung cancer 7, gastric cancer 17,glioblastoma 18, etc. 19-25, regulated by hypoxia-inducible factor-1α (HIF-1α) mediated 26 or Wnt/β-catenin signaling 27 and contributed to chemoresistance of ovarian cancer by activating EGFR 28.