Most TALE subfamilies (including Meis1, Meis2, and Pbx2) are upregulated in a set of neuroblastoma cell lines, suggesting that the regulation of TALE transcription is functional in tumorigenesis (Jones et al., 2000; Spieker et al., 2001; Geerts et al., 2003; Berdasco et al., 2009). This evidence concerns the gene MEIS2 and neuroblastoma.