Hoxa9 hypermethylation was also reported in the promoter methylation analysis of OSCC patient tissues (Guerrero-Preston et al., 2011) and salivary rinses (Schussel et al., 2013), which leads to the growth advantage of the tumor, and an increase in metastasis (Uchida et al., 2014). This evidence concerns the gene HOXA9 and neoplasm.