ESR1 and breast cancer: However, in Breast cancer, we compared the jDR clustering results with two subtypings: the ER/PR/HER-2 subtyping based on Estrogen Receptor (ER), Progesterone Receptor (PR) and HER-2 immunohistochemistry markers25, and the Cluster of Cluster Assignment (COCA) integrative classification performed by the TCGA consortium26.