Although enormous miRNA studies in MM have been focused on revealing their role in MM-related drug resistance, only a few studies addressed the possible mechanisms, for example, p53-related signaling pathway [96, 103, 104], NF-κB signaling pathways [23], JNK/SAPK signaling pathway [90], chromosomal deletions [105, 106], as well as by regulating cell cycle, proliferation or survival [107–109]. Here, MAPK8 is linked to Miyoshi myopathy.