Moreover, LMP1 proteins with mutant CTAR1 and CTAR2 domains, known to be critical for activation of NF-κB by LMP1 (ref. 15; Supplementary Fig. 2), induced significant lower SSTR2 expression compared with NPC transfected with wild-type LMP1 (Fig. 2f, g). The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.