Fig. 2 A–D presents the comparison showing agreement between model predictions and clinical data for Ang II, neutrophils, CD8+ T cells, and IL6 levels. Fig. 2E further validates model predictions for the evolution of IL6 in COVID-19 patients admitted to the Intensive Care Unit of Massachusetts General Hospital. The use of retrospective patient data was deemed exempt by our institutional review board. Informed consent was waived (41). This evidence concerns the gene CD8A and COVID-19.