AGT and COVID-19: Fig. 2 A–D presents the comparison showing agreement between model predictions and clinical data for Ang II, neutrophils, CD8+ T cells, and IL6 levels. Fig. 2E further validates model predictions for the evolution of IL6 in COVID-19 patients admitted to the Intensive Care Unit of Massachusetts General Hospital. The use of retrospective patient data was deemed exempt by our institutional review board. Informed consent was waived (41).