ENPP2 and Alzheimer disease: Among the 162 DAM genes, we found only 8 genes were deregulated in AD precuneus, and unexpectedly, all of them (APBB2, ARAP2, DHCR7, ENPP2, MYO1E, CDS22, KCNJ2, and SLC44A1) were downregulated (Fig. 5b).