INS and Hypoglycemia: This underscores that there is still work to be done in terms of avoiding clinical inertia and recurrence of hypoglycemic events in this patient group, questioning the use of secretagogue-based therapy and some combinations like SU + insulin, reinforcing the importance to increase the number of anti-hyperglycemic agents with low risk of hypoglycemia as a therapeutic option [35, 36] and developing educational and/or support programs for patients/caregivers, especially designed for populations at higher risk, in order to minimize the risk for complications.