Other new molecular sub-classifications within GIST are oncogenic RTK translocation associated GIST or quadruple wild-type GISTs and quintuple wild-type GIST which refer to GISTs that are devoid of mutations in KIT/PDGFRA/RAS-MAPK pathway/SDH complex and oncogenic RTK translocations [5–7]. This evidence concerns the gene SDHB and gastrointestinal stromal tumor.