To understand the effect of the m6A pathway on this AD fly model, we crossed Drosophila orthologs of METTL3, METTL14 (m6A writers), and YTHDF (m6A reader) RNAi flies with the AD fly (there is only one ortholog of the YTHDF proteins in Drosophila). This evidence concerns the gene METTL3 and Alzheimer disease.