In cBioPortal database, we found that GAP43 was mutated in CRC cancer tissues with the 1–3% frequency (Supplementary Fig. S1b), and in Oncomine, compared with normal colorectal tissues, we found that the expression of GAP43 was significantly repressed in CRC tissues (Supplementary Fig. S1c). This evidence concerns the gene GAP43 and colorectal carcinoma.