VHL and nonpapillary renal cell carcinoma: More than 90% of ccRCC tumors show constitutive activation of the hypoxia-inducible factor (HIF) proteins resulting from biallelic inactivation of the tumor suppressor von Hippl-Lindau (VHL) gene, which underline the clear-cell phenotype of ccRCC because of abnormal lipid and glycogen accumulation, also accounting for its trait of resistance to chemotherapy and radiotherapy [19–22].