NCOA4 depletion was reported to cause a cell disturbed ferroptosis process by eliminating the accumulation of intracellular free iron, glutathione and reactive oxygen species (ROS), and it was closely related to the tumorigenesis and progression of various cancers such as prostate cancer, ovarian cancer and breast cancer [8, 18]. The gene discussed is NCOA4; the disease is Familial prostate cancer.