A plethora of recent studies have demonstrated the relationship between H19 and their specific modulated targets/pathways in digestive system cancers, such as induction of epithelial–mesenchymal transition (EMT), interference with apoptosis, regulation of the expression of MDR genes, and transfer of exosomes (Ren et al. 2018; Li et al. 2018). Here, H19 is linked to digestive system cancer.