According to a recent study (Ren et al. 2018), exosomes derived from carcinoma-associated fibroblasts (CAFs) transferred H19 to CRC cells, and H19 activated the downstream Wnt/β-catenin signaling pathway through competitive sponging of miR-141 to induce proliferation, invasion and metastasis of CRC stem cells; this promoted the stemness of CRC stem cells and induced oxaliplatin resistance in CRC cells in vitro and in vivo. Here, H19 is linked to carcinoma.