Different from the above mechanism, H19 can combine with miR-194-5p and mediate the silent information regulator 1 (SIRT1) dependent autophagy pathway to inhibit apoptosis of CRC cells and enhance their chemoresistance; this increased the IC50 of 5-Fu by 227.43% in H19 transfecting group compared with 5-FU sensitive cells HCT8 (Wang et al. 2018a, b). This evidence concerns the gene H19 and colorectal carcinoma.