In our study, we first analyze the expression profiles of ARGs from TCGA and obtained a 17 autophagy-related prognostic genes (ATG16L1, FADD, GABARAPL2, NKX2–3, MYC, MAPK8IP1, WDR45B, MTMR14, HGS, USP10, NPC1, BIRC5, BNIP3, ATG3, RAB24, ULK3 and RUBCN) by univariate Cox regression analysis for detecting the prognosis of prostate cancer patients. The gene discussed is WDR45B; the disease is Familial prostate cancer.