After matching multiple covariates (i.e., age, sex, AST, ALT, PT, platelet, creatinine, hypertension, presence of ascites, HBV infection, and Child-Pugh class) in the pooled cohort, 161 patients with PVTT were matched with 309 controls without PVTT (Supplementary Table 1). This evidence concerns the gene F2 and Hypertension.