Although the incidence of breast cancer is higher in the Americas and Europe than in the Asian continent [38, 39], it is interesting to note that the association between ATM variants and breast cancer is greater in Asian countries than in American and European countries in all three sub-groups analyses that is probably due to racial differences, environmental conditions, patterns of life and the effects of other genes or specific haplotype combinations in that region [39]. This evidence concerns the gene ATM and breast cancer.