Also, the evaluation of the effect of different variants of ATM Gene on the incidence of breast cancer shows that c.7271 T > G has the highest association with an OR of 27.97 (95% CI: 5.01–35.07; I Square: 62.0%; PI square: 0.105) and L546V has the lowest association with an OR of 0.37 (95% CI 0.19–0.73; 0.032; I Square:58.9; PI square: 0.105) (Table 3). Here, ATM is linked to breast cancer.