The same extract and its purified compounds were also active on other two T2D targets, i.e., free fatty acid receptor-1 (FFAR-1) and glucokinase (GK) responsible for the stimulation of pancreatic β-cells to secrete glucose-dependent insulin and the preservation of glucose homeostasis at pancreatic and liver level, respectively. This evidence concerns the gene INS and type 2 diabetes mellitus.