IL6 and obesity due to melanocortin 4 receptor deficiency: The results indicated differences among the genotypes, but generally all samples reduced the production of some target parameters associated to obesity such as the main pro-inflammatory mediators in adipose tissue, i.e., TNF-α, prostaglandin E2, interleukin-6 (IL-6), nitric oxide (NO), LPS, monocyte chemoattractant protein-1 (generally present in high level in obese subjects), leptin, and enhanced the level of adiponectin (an anti-inflammatory mediator).