The genetic disruption or chemical inhibition of SLC3A2/ SLC7A11 HATC leads to autophagy and ferroptosis in the different types of tumor cells, including endometrial, colorectal, pancreatic cancer, and hepatocellular carcinoma (HCC) through inhibition of mTOR/p70S6K signaling [45,51,56,57,78,80,81]. Here, RPS6KB1 is linked to hepatocellular carcinoma.