HT-1376 has FGFR-3 (FGF3 receptor), PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), TERT and p53 mutations and stems from muscle-invasive cancer, whereas J82 stems from cancer infiltrating tissues around the bladder and has PIK3CA, TERT and p53 mutations (Table 1). Here, PIK3CA is linked to cancer.