In the study by Schwaab et al. [3], the most frequently affected genes were TET2, SRSF2, ASXL1, CBL, and RUNX1. In advanced SM, 21/27 patients (78%) carried ≥3 variants, and 11/27 patients (41%) exhibited ≥5 variants. The gene discussed is ASXL1; the disease is systemic mastocytosis.