KIT and myeloid neoplasm: From a molecular point of view, SM can be divided into three groups: (i) SM with the KIT p.D816V variant detected only in MC and a few other cells, (ii) multi-lineage SM where KIT p.D816V is also detected in most or all other myeloid cells in the BM and blood, (iii) and multi-mutated SM where, in addition to KIT p.D816V, mutations in other myeloid malignancy-related genes, such as TET2 or ASXL1 are found [14,15,16,17,18].