Implicated in the regulation of numerous metabolic pathways including T2D, hepatic lipid accumulation, and atherosclerosis [23], fatty acid-binding protein 4 (FABP4), and sterol regulatory element-binding protein 1 (SREBP1) have potential dominant roles in fatty liver disease promotion in rats and humans [33]. The gene discussed is SREBF1; the disease is type 2 diabetes mellitus.