Moreover, FASN can activate nucleotide-binding domain leucine-rich repeat domain containing 3 (NLRP3) inflammasome-mediated caspase-1 and increase expression of NLRP3 and levels of proinflammatory cytokines (e.g., interleukin (IL)-1β and IL-18) in obesity-induced inflammation through the inflammatory signal pathway [53]. The gene discussed is CASP1; the disease is obesity due to melanocortin 4 receptor deficiency.