In CKD, hypertension, cardiovascular dysfunction, inflammation, abnormal vitamin D metabolism, hyperparathyroidism, hyperphosphatemia, and high serum levels of fibroblast growth factor 23 (FGF23) have been blamed for the extremely high morbidity and mortality of these patients, particularly in CKD stages 3 to 5. This evidence concerns the gene FGF23 and hypertensive disorder.