APP and Alzheimer disease: Furthermore, transgenic mouse models of AD, including (PSEN1 (M146V) KI, Thy1.2-AβPP (swe) and triple (PSEN1 (M146V) KI, Thy1.2- AβPP (swe), and Thy1.2-tau (P301L), exhibit a significant increase in CRMP2 phosphorylation in the hippocampus and cortex [2].