The reduced 18:2/20:4 ratio in RA patients was suggested to be related to the degree of inflammation, due to an increase in the FA desaturation/elongation process, which could be the result of higher insulin levels (stimulates desaturation) that have been found in RA patients, or due to an increased synthesis of eicosanoids [104,105]. This evidence concerns the gene INS and rheumatoid arthritis.