MAPT and Alzheimer disease: Aβ1-42 and QUIN stimulate cytokine production [69] and increases the hyperphosphorylation of tau proteins via NMDA receptor overactivation, leading to glutamate excitotoxicity in patients with AD [70] and it plays a pivotal role in lipid peroxidation and ROS production, in an NMDAR-dependent or -independent manner, assisting to the pathogenesis of AD [71,72].